layman other binary overlay

hlw … how calculate linux or layman handels other binary based overlay which r created with dffrnt cflags ? … like pentoo nd other binary host nd overlay … will installing soft from those overlay require compiling ? … i am on calculate default cflags …
and can i add other binary host to work on calculate ? … if the cflag match mine ( nd using binary soft from 2core intel in corei3 ) ?